Fish diseases are considered one of the main persistent threats to aquaculture, representing an estimated annual loss of US $ 6 billion worldwide. While there has been a drastic reduction in the use of antimicrobials in recent years due to vaccination and the improvement of cultivation practices, the use of antibiotics remains a common practice in some countries to prevent and mitigate possible productive and economic losses from disease. Antibiotic prophylaxis represents a high cost for fish farmers and causes undesirable side effects, such as bioaccumulation of drug residues, pollution and increased antibiotic resistance, posing these serious threats to health and food safety. world. Under this scenario, the growth of the aquaculture industry will inevitably involve the implementation of innovative and sustainable production strategies, and functional foods will be among the most promising. Within the range of additives with immunomodulatory properties, in this day we will focus on those of plant origin or also known as phytogenic.